Artificial Intelligence and Biotechnology are redefining what it means to be human, and succeed in life and work. Education curricula must be deeply redesigned for versatility and adaptability, implying all of the four dimensions of Knowledge, Skills, Character and Meta-Learning, and the interplay between them. Our future requires holistic humans who are like “Swiss Army knives”: multi-faceted capabilities in many domains, broadly and deeply, with the ability to continuously reflect and adapt by having “learned how to learn”. Charles Fadel is a global education thought leader and author, futurist and inventor; founder Center for Curriculum Redesign; visiting scholar Harvard GSE; chair education committee BIAC/OECD; co-author “Four-Dimensional Education” (now in 15 languages) and best-selling “21st Century Skills”; founder Fondation Helvetica Educatio. He was formerly: Global Education Lead at Cisco Systems, worked with education entities in thirty countries; visiting scholar at MIT; angel investor. Holder of BSEE, MBA, 7 patents. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at